Regulating signal enhancement with coordination-coupled deprotonation of a hydrazone switch.
نویسندگان
چکیده
Proton relay plays an important role in many biocatalytic pathways. In order to mimic such processes in the context of molecular switches, we developed coordination-coupled deprotonation (CCD) driven signaling and signal enhancement sequences. This was accomplished by using the zinc(ii)-initiated CCD of a hydrazone switch to instigate an acid catalyzed imine bond hydrolysis that separates a quencher from a fluorophore thus leading to emission amplification. Because CCD is a reversible process, we were able to show that the catalysis can be regulated and turned "on" and "off" using a metalation/demetalation cycle.
منابع مشابه
Regulating signal enhancement with coordination-coupled deprotonation of a hydrazone switch† †Electronic supplementary information (ESI) available. CCDC 862857 and 990962. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02882a Click here for additional data file. Click here for additional data file.
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ورودعنوان ژورنال:
- Chemical science
دوره 6 1 شماره
صفحات -
تاریخ انتشار 2015