Regulating signal enhancement with coordination-coupled deprotonation of a hydrazone switch.

نویسندگان

  • Justin T Foy
  • Debdas Ray
  • Ivan Aprahamian
چکیده

Proton relay plays an important role in many biocatalytic pathways. In order to mimic such processes in the context of molecular switches, we developed coordination-coupled deprotonation (CCD) driven signaling and signal enhancement sequences. This was accomplished by using the zinc(ii)-initiated CCD of a hydrazone switch to instigate an acid catalyzed imine bond hydrolysis that separates a quencher from a fluorophore thus leading to emission amplification. Because CCD is a reversible process, we were able to show that the catalysis can be regulated and turned "on" and "off" using a metalation/demetalation cycle.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparative assessment of the accuracy of maximum likelihood and correlated signal enhancement algorithm positioning methods in gamma camera with large square photomultiplier tubes

Introduction: The gamma cameras, based on scintillation crystal followed by an array of photomultiplier tubes (PMTs), play a crucial role in nuclear medicine. The use of square PMTs provides the minimum dead zones in the camera. The camera with square PMTs also reduces the number of PMTs relative to the detection area. Introduction of a positioning algorithm to improve the spat...

متن کامل

A Closed Loop Control of Quadratic Boost Converter Using PID Controller

This paper presents an implementation of open loop and closed loop control of Quadratic boost converter using PID controller.  Quadratic boost converter consists of boost converter and fly back converter driven by a single switch. Quadratic boost converter QBC is designed especially for regulating the DC interface between various micro sources and dc-ac inverter to electricity grid. Quadratic b...

متن کامل

An Improved Control Approach for Dual Mechanical Coupled BLDC Motor With Nine-Switch Inverter

This paper presents the control approach for single inverter dual coupled brushless DC motors (DCBLDC) drive system. One of the basic requirements of such systems, is the power balance between two motors and on the other hand, minimizing mechanical fluctuations in order to avoid mechanical equipment damage especially in the state of mechanical resonance. This paper also presents an improved for...

متن کامل

Deprotonation of a dinuclear copper complex of 3,5-diamino-1,2,4-triazole for high oxygen reduction activity.

A dinuclear copper(II) complex of 3,5-diamino-1,2,4-triazole is one of the highly active copper-based catalysts for the oxygen reduction reaction (ORR) in basic solutions. Our in situ X-ray absorption near edge structure measurements revealed that deprotonation of the triazole ligand might cause coordination geometrical changes, resulting in the enhancement of the ORR activity.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chemical science

دوره 6 1  شماره 

صفحات  -

تاریخ انتشار 2015